[ACIE] 我室徐海超教授发表论文:Scalable Rh(III)‐Catalyzed Aryl C–H Phosphorylation Enabled by Anodic Oxidation‐Induced Reductive Elimination

2019年09月14日

我室徐海超教授在 ACIE 上发表论文:Scalable Rh(III)‐Catalyzed Aryl C–H Phosphorylation Enabled by Anodic Oxidation‐Induced Reductive Elimination

文章链接:https://onlinelibrary.wiley.com/doi/10.1002/anie.201909951

摘要:

Transition metal‐catalyzed C–H phosphorylation remains an unsolved challenge. Reported methods are generally limited in scope and require stoichiometric silver salts as oxidants. Herein we report an electrochemically driven Rh(III)‐catalyzed aryl C–H phosphorylation reaction, which proceeds through H2 evolution obviating the need for stoichiometric metal oxidants. The method is compatible with a variety of aryl C–H and P–H coupling partners and particularly useful for synthesizing triarylphosphine oxides from diarylphosphine oxides, which are often difficult coupling partners for transition metal‐catalyzed C–H phosphorylation reactions. Experimental results suggest that the mechanism responsible for the C–P bond formation involves an oxidation‐induced reductive elimination process.