[Nature communications] 我室徐海超教授发表论文:Tailored cobalt-salen complexes enable electrocatalytic intramolecular allylic C–H functionalizations

发布日期:2021年06月24日   浏览次数:

我室徐海超教授在 Nature communications 上发表论文:Tailored cobalt-salen complexes enable electrocatalytic intramolecular allylic C–H functionalizations

摘要:Oxidative allylic C–H functionalization is a powerful tool to streamline organic synthesis as it minimizes the need for functional group activation and generates alkenyl-substituted products amenable to further chemical modifications. The intramolecular variants can be used to construct functionalized ring structures but remain limited in scope and by their frequent requirement for noble metal catalysts and stoichiometric chemical oxidants. Here we report an oxidant-free, electrocatalytic approach to achieve intramolecular oxidative allylic C–H amination and alkylation by employing tailored cobalt-salen complexes as catalysts. These reactions proceed through a radical mechanism and display broad tolerance of functional groups and alkene substitution patterns, allowing efficient coupling of di-, tri- and even tetrasubstituted alkenes with N- and C-nucleophiles to furnish high-value heterocyclic and carbocyclic structures.

文章链接:https://www.nature.com/articles/s41467-021-24125-5