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高锦豪

2020年02月06日

教授
办公室:卢嘉锡楼528 
电话:2180278 
Email:jhgao@xmu.edu.cn
通讯地址:厦门大学固体表面物理化学国家重点实验室
个人简历

厦门大学教授 (2010 - )
斯坦福大学博士后 (2008 - 2010)
香港科技大学博士 (2008)
南京大学学士 (2004)


研究兴趣
影像化学生物学;磁共振造影剂;19F磁共振探针;金属化学生物学;肿瘤诊疗;分子探针


主要代表论文

(1) Zhu, X. L.; Tang, X.; Lin, H. Y.; Shi, S.; Xiong, H.; Zhou, Q.; Li, A.; Wang, Q.; Chen, X.; Gao, J. H.* A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Enables Detection and Imaging of Biological Targets. Chem 2020, 6, in press.

(2) Sun, C. J.; Lin, H. Y.; Gong, X. Q.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J. H.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.

(3) Tang, X.; Gong, X. Q.; Li, A.; Lin, H. Y.; Peng, C. Y.; Zhang, X.; Chen, X.; Gao, J. H.* Cascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification. Nano Lett. 2020, 20, 363-371.

(4) Zhou, Z.; Yang, L.; Gao, J. H.;* Chen, X.* Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567.

(5) Zhang, Y. J.;* Zhang, L.; Gao, J. H.;* Wen, L. P.* Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy. Acc. Chem. Res. 2019, 52, 3164-3176.

(6) Wei, R.; Gong, X.; Lin, H.; Zhang, K.; Li, A.; Liu, K.; Shan, H.; Chen, X.; Gao, J. H.* Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery. Nano Lett. 2019, 19, 5394-5402.

(7) Li, A.; Tang, X.; Gong, X.; Chen, H.; Lin, H. Y.;* Gao, J. H.* A Fluorinated Bihydrazide Conjugate for Activatable Sensing and Imaging of Hypochlorous Acid by 19F NMR/MRI. Chem. Commun. 2019, 55, 12455-12458.

(8) Yang, Z.; Lin, H.; Huang, J.; Li, A.; Sun, C.; Richmond, J.; Gao, J. H.* A Gadolinium-Complex-Based Theranostic Prodrug for In Vivo Tumour-Targeted Magnetic Resonance Imaging and Therapy. Chem. Commun. 2019, 55, 4546-4549.

(9) Yang, L.; Wang, Z.; Ma, L.; Li, A.; Xin, J.; Wei, R.; Lin, H.; Wang, R.; Chen, Z.; Gao, J. H.* The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles. ACS Nano 2018, 12, 4605-4614.

(10) Zhou, Z.; Wu, C.; Liu, H.; Zhu, X.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.

(11) Zhao, Z.; Wang, X.; Zhang, Z.; Zhang, H.; Liu, H.; Zhu, X.; Li, H.; Chi, X.; Yin, Z.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T1 Imaging. ACS Nano 2015, 9, 2749-2759.

(12) Zhou, Z.; Zhao, Z.; Zhang, H.; Wang, Z.; Chen, X.; Wang, R.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.

(13) Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z. Y.; Hu, J.; Chi, X. Q.; Ni, K. Y.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-Performance T2 Contrast Agents for Magnetic Resonance Imaging. Nat. Commun. 2013, 4, 2266.

(14) Zhou, Z. J.; Wang, L. R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhao, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-Oxide-Based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.

(15) Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.

(16) Gao, J. H.; Gu, H. W.; Xu, B.* Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications. Acc. Chem. Res. 2009, 42, 1097-1107.

(17)  Gao, J. H.; Liang, G. L.; Cheung, S. C.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.* Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent. J. Am. Chem. Soc. 2008, 130, 11828-11833.

(18)  Gao, J. H.; Zhang, W.; Huang, P. B.; Zhang, B.; Zhang, X. X.; Xu, B.* Intracellular Control of Fluorescent Magnetic Nanoparticles. J. Am. Chem. Soc. 2008, 130, 3710-3711.

(19)  Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures. J. Am. Chem. Soc. 2007, 129, 11928-11935.

(20)  Gao, J. H.; Liang, G. L.; Zhang, B.; Kuang, Y.; Zhang, X. X.; Xu, B.* FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells. J. Am. Chem. Soc. 2007, 129, 1428-1433.


目前承担课题

国家重大科学研究计划子课题:可控特性纳米材料的设计合成及其诱导自噬的相关性研究
“973”项目课题(学术骨干):乳腺癌分子分型标志物的多功能分子探针研究
国家自然科学基金优秀青年科学基金:生物功能无机纳米材料
国家自然科学基金面上项目:高性能磁性纳米药物的构建及其肿瘤诊疗一体化应用研究
国家自然科学基金重点项目(第二负责人):以肝癌干细胞为靶标的多模态成像导航在肝癌介入治疗的研究
福建省杰出青年科学基金:多功能智能纳米药物控释系统的基础研究
霍英东基金会青年教师基金应用研究课题:纳米生物医用材料的肿瘤诊疗应用研究