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Electrochemical, Spectroscopic and Surface Imaging Studies of Antimicrobial Peptides Incorporated into Biomimetic Membranes Supported at gold Electrode

2019年11月11日

报告题目:Electrochemical, Spectroscopic and Surface Imaging Studies of Antimicrobial Peptides Incorporated into Biomimetic Membranes Supported at gold Electrode

报告人:Prof. Jacek Lipkowski, 加拿大皇家科学院院士,加拿大奎尔夫大学教授

时间:2019-11-13 10:00

地点:卢嘉锡楼202报告厅

报告摘要:

Antimicrobial peptides (AMPs) are important components of the innate immunity which is the first line of defense of all organisms, including plants and humans. AMPs have typically 12-50 amino acids and about 50 % of them are hydrophobic. They are involved in antiseptic, immune modulatory and chemotactic processes. They aggregate in the cellular membrane of pathogens and form pores leading to the cell death caused by the osmotic shock and leakage of intracellular content. In this lecture I will review our recent studies of antimicrobial peptides such as gramicidin, alamethicin, trichogin and valinomycin incorporated into phospholipid membranes supported at a gold electrode surface. In this architecture, we were able to apply scanning probes such as scanning tunneling microscopy (STM) and atomic force microscopy (AFM), photon polarization infrared reflection absorption spectroscopy (PM IRRAS) and electrochemical techniques to determine the nature of peptide aggregation, orientation and conformation in phospholipid monolayers and bilayers. We will present molecular resolution STM and AFM images of pores formed by antimicrobial peptides in phospholipid membranes. We will also show a correlation between the conductivity of ion channels formed by antimicrobial peptides in gold supported bilayers to their orientation and conformation in such membranes.



报告人简介:

Prof. Jacek Lipkowski, Professor of chemistry at the University of Guelph. Ph.D. (1974) and D.Sc. (1978), University of Warsaw Poland, since 1983 associate and later professor in the Department of Chemistry and Biochemistry, author of about 230 papers and recipient of a number of national and international awards. His research covers a broad area of interfacial electrochemistry and bioelectrochemistry. He combines electrochemical and spectroscopic techniques to study adsorption of ions and neutral molecules at electrified interfaces. He studies atomic scale processes, such as adsorption or electron and ion transfer, which are involved in the electrolytic production of metals, corrosion and energy conversion in fuel cells or batteries with a focus on metals such as Pt, Au, Ag, and Cu and their alloys. Molecular absorption and florescence spectroscopies and Fourier transform infrared spectroscopy are used to study the orientation of organic molecules adsorbed at electrode surfaces. His research is a balanced mixture of electrochemistry, surface analysis, surface spectroscopy, and materials science, and tackles projects which mix both fundamental and applied science.



报告人 Prof. Jacek Lipkowski 时间 11月13日上午10:00
地点 卢嘉锡楼202报告厅 月份 11
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