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Engineered for autophagy research: a biologist’s rendezvous with materials science

发布日期:2021年04月12日   浏览次数:

报告题目:Engineered for autophagy research: a biologist’s rendezvous with materials science

报告人:温龙平教授, 华南理工大学/中国科学技术大学

时间:2021年04月15日15:00

地点:卢嘉锡楼202报告厅

报告摘要:

Engineered materials, nano or otherwise, have greatly aided the advancement of life science research. The ability to tune the physicochemical properties of materials, so as to achieve desired modulation of a specific biological process, is critically important. In this talk I will present three case studies, in which we successfully implemented materials engineering principles for autophagy research. In the first example, a surface-coating peptide, discovered through phage display, was used to control whether and how much autophagy can be induced by rare earth nanoparticles in cancer cells. In the second scenario, we engineered a special Cu-Pd alloy nanomaterial with a particular shape and composition, which elicited pro-survival autophagy and enabled optimized photothermal therapy of drug-resistant cancer when combined with an autophagy inhibitor. And finally, I will briefly describe our unpublished work, in which we leverage the AIE principle for achieving transfection-free flow cytometric sorting of live and functionally-competent cells that differ in the autophagy level. For a biologist with little training in chemistry, the rendezvous with materials science has been mind-boggling and, at the same time, fulfilling.

报告人简介:

温龙平,1982年2月厦门大学本科毕业,同年CUSBEA项目赴美留学。美国加州大学洛杉矶分校(UCLA)博士,中国科学技术大学/华南理工大学二级教授,博士生导师,中科院“百人计划”,两任科技部“973”项目首席科学家。从事纳米材料生物学效应及功能肽介导的药物输运研究。近年来在Nature Materials、Nature Biotechnology、Nature Communications、Accounts of Chemical Research、Nano Letters、Autophagy、ACS Nano等杂志发表SCI论文100多篇,包括通讯/共通讯作者论文70多篇。申报国内外专利近20项,授权15项。获得2006年度“中国基础研究10大新闻”(后面更名为“中国科学十大进展”)等多项奖励。

报告人 温龙平教授, 华南理工大学/中国科学技术大学 时间 2021年04月15日15:00
地点 卢嘉锡楼202报告厅 月份 4
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